Better detection of reduced motor functioning in brain tumor survivors based on objective motor assessments:An incentive for improved standardized follow-up

Long-term sequelae are well-known in childhood brain tumor survivors, but motor functioning remains poorly described. This cross-sectional study aimed to assess objective motor functioning, patient-specific risk factors, and parental perceptions. Fifty-two childhood brain tumor patients (pilocytic astrocytoma, medulloblastoma, and other types) who were at least 6 months out of treatment were evaluated. Mean age at testing was 11.7 years. Objective motor functioning was assessed with the Movement Assessment Battery for Children (MABC-2-NL) and/or Bruininks-Oseretsky test of motor proficiency (BOT-2). Functional walking capacity was assessed with the 6-min walk test (6MWT). Parent-reported motor functioning was addressed using the ABILHAND-Kids, ABILOCO-Kids questionnaires, and a standardized anamnesis. Patients showed impaired motor functioning in all domains (p < 0.001). Regarding risk factors, younger age at diagnosis (< 5 year) was significantly associated with lower scores on body coordination (p = 0.006). Adjuvant treatment resulted in lower scores for fine manual control of the BOT-2 (p = 0.024) and balance of MABC-2-NL (p = 0.036). Finally, questionnaires revealed an underestimation of motor problems as perceived by the parents. In conclusion, many children who are in follow-up for a brain tumor show impaired motor functioning on multiple aspects, with younger age at diagnosis and adjuvant treatment as specific risk factors. Based on the questionnaires and anamnesis, motor problems appear to be underestimated by the parents. Conclusion: These findings point to the need for timely prospective screening of motor functioning. Based on a screening assessment, adequate rehabilitation programs can be applied in childhood brain tumor survivors, aiming to reduce the adverse impact on their daily lives, both for functional activities and cardiovascular fitness. What is Known: • A pediatric brain tumor and its treatment are associated with potential long-term motor sequelae. • Test assessments could enable us to objectify motor functioning of these patients. What is New: • Pediatric brain tumors survivors show lower motor performance compared to the norm, which is often underestimated by parents. • Younger age at diagnosis and adjuvant treatment could be specific risk factors

Frontiers of Entrepreneurship Research 2010

In contrast to the Affect Infusion Model, popular advertising planning grids suggest that emotional advertising is effective for low involvement and hedonic products, but not for high involvement or utilitarian products. In two experiments, 400 and 392 consumers respectively evaluate a non-emotional and a product-congruent or product-incongruent emotional appeal promoting four different product types. In a third study, 909 respondents evaluate 323 existing TV commercials. The findings confirm expectations based on the Affect Infusion Model and indicate that for none of the product types negative effects of emotional advertisements appear. However, emotional ads do work better for some than other product types. In addition to clearing out the moderating role of product type, this paper contributes to the literature by showing that previous poorer results of emotional ads for some products may be partly due to less positive attitudes towards the products themselves instead of to the inappropriateness of the appeal

Implementatie van de Preventiemodule in de praktijk

status: publishe

Combined membrane filtration and 265 nm UV irradiation for effective removal of cell free antibiotic resistance genes from feed water and concentrate

The removal of cell free DNA (plasmids) carrying antibiotic resistance genes (ARGs) was investigated at bench-scale using ultrafiltration (UF), nanofiltration (NF) and reverse osmosis (RO) membranes commonly applied in water reuse applications. The removal of the plasmid spiked to ultrapure water was determined using a direct qPCR method. More than 99% plasmid removal was achieved by membranes with 1 kDa molecular weight cut off (MWCO). Membranes with lower MWCO showed complete removal under the specific experimental conditions, reaching a maximum log reduction value above 6.6. The concentrate from membrane filtration was further subjected to UV-LED irradiation at 265 nm. The required fluence for 1 log damage was 73 mJ/cm2 for the 267 target bp segment and 23 mJ/cm2 for the 601 target bp segment, respectively. With these two DNA segments, the inactivation rate per segment length was higher for the larger segment, in accordance with a higher pyrimidine and TT content, compared with the smaller fragment. Target DNA was not detectable anymore when using 100 and 300 mJ/cm2 for the 601 and 267 bp segments respectively. The results indicate that membrane filtration, combined with UV-LED treatment of the concentrate, can be an effective measure to remove and inactivate ARGs from water to prevent their release to the environment.publishedVersio

Correction to: Better detection of reduced motor functioning in brain tumor survivors based on objective motor assessments: An incentive for improved standardized follow-up

Correction to: European Journal of Pediatrics (2022) 181:2731–2740 https://doi.org/10.1007/s00431-022-04472-1 In the original published version of the above article, the authors’ names were incorrectly presented. The names are now corrected and cited correctly as, “Gielis, M., Dirix, V., Vanderhenst, E., Uyttebroeck, A., Feys, H., Sleurs, C., Jacobs, S.